ISSN 2575-6206
Vol. 10, Issue 4, 2026October 21, 2026 CDT
Evolution-informed rescue drug design: exploiting acquired resistance to develop more selective and resistance-durable targeted therapies
Evolution-informed rescue drug design: exploiting acquired resistance to develop more selective and resistance-durable targeted therapies
Evolution-informed drug designAcquired drug resistanceTargeted cancer therapyResistance mutationsMutant-selective inhibitorsCancer drug discoveryEvolutionary selectionFunctional constraintsArtificial Intelligence in drug discoveryResistance-durable therapeutics
Articles in Vol. 10, Issue 4, 2026
Vol. 10, Issue 4, 2026
- Randomly Wired Neural Networks for IMRT 3D dose prediction in oropharyngeal cancerDev J PakshootraKrithin J PakshootraYong H Lee
- Engineering immune cells as dynamic therapies: An evolution-guided framework for temporally programmed CAR T cellsArushi Saini
- Artificial Intelligence in genetic healthcare: toward adaptive and systems-level genomic medicineIshanvi TupiliDeekshitha RavipatiKarthik ManguBhumandeep Kour
- _In-situ_, grafted, and nonselective synthesis of Ag–TiO₂/SBA-15: Differences in catalyst properties and photocatalytic performanceWoosung Choi
- Safe host integration in islet tissue engineering for Type 1 Diabetes Mellitus: emerging technologies and a constraint-guided hybrid islet frameworkWallace Lung
- Cognitive-congestion language profiling in ADHD: lexical signal auditing and negative-manifold specificity testingSieun Ju
- Predicted-gender information in ASD facial-image classification: multitask performance, shuffled-label controls, and representation analysisAaryan VermaClayton Greenberg
- When do drug holidays delay resistance? A calibrated model of BRAF V600E melanomaEthan Y Yang
- Evolution-informed rescue drug design: exploiting acquired resistance to develop more selective and resistance-durable targeted therapiesAdiv Patel
Patel, Adiv. 2026. “Evolution-Informed Rescue Drug Design: Exploiting Acquired Resistance to Develop More Selective and Resistance-Durable Targeted Therapies.” Journal of High School Science 10 (4): 326–56. https://doi.org/10.64336/001c.172802.